LifeView - PGT-SR | Testing for Structural Rearrangements

Individuals who carry a structural rearrangement have chromosomes arranged in a different order. These rearrangements may increase the chance of fertility problems and miscarriage, and may lead to health problems following delivery.

Chromosome rearrangements are identified through a test called a karyotype. This testing may be ordered to address a history of recurrent pregnancy loss or following a pregnancy with a chromosome problem.

Individuals who are carriers of balanced chromosome rearrangements have a higher chance of creating embryos with extra or missing genetic material; leading to fertility problems, pregnancy loss and health problems in an ongoing pregnancy.

There are different types of structural rearrangements that can be addressed with PGT-SR testing

Reciprocal translocations: Chromosome material from two different chromosomes have swapped places
Inversions: Chromosome material is “flipped over” within a chromosome
Robertsonian translocations: Two different chromosomes are attached together

Why choose LifeView™ testing?

LifeView PGT-SR screens for chromosome problems by looking at the total amount of chromosome material, called copy number analysis, as well as looking for patterns associated with genetic variation across the genome, called genotyping. These multiple analysis methods allow for:

Distinguish between balanced and euploid embryos - LifeView testing is able to identify embryos with the usual number of chromosomes in the usual order vs embryos that inherited the balanced chromosome rearrangement.
Increased accuracy - Testing for chromosome problems associated with a parental rearrangement is greater than 99% accurate.
Identify uniparental disomy - Uniparental disomy means an embryo has two copies of chromosomal material from one parent instead of both egg and sperm. The chance of uniparental disomy is higher in individuals with a balanced chromosome rearrangement and can result in health problems in an ongoing pregnancy.

Testing Process

Step 1

Talk to your doctor about using LifeView PGT-SR.

Step 2

Our client specialist will work closely with your IVF team to address your specific needs.

Step 3

Embryos are produced through an IVF cycle. A small sample from each embryo is sent for a LifeView analysis.

Step 4

Once the analysis is complete, a report with your results is sent directly to your IVF team. Lifeview Genetic Counselors are always available to further discuss your report.

PGT-SR

Designed to screen for chromosome abnormalities caused by known structural rearrangements in a parent.